Video footage shared on social media shows the warehouse, which is located just outside of Moscow, caught by a large blaze. The unit is owned online store Ozon.
This is said to be the Russian equivalent of Amazon.
Commentator Igor Sushko reported in a post on Twitter that the fire was covering almost nine acres.
In other footage shared online, firefighters can be seen battling the blaze.
The cause of the fire is not yet known.
Ozone is one of Russia’s first e-commerce companies.
It was originally established in 1998 as an online bookstore.
The company was one of the three biggest online retail platforms in Russia in 2019, according to the Moscow Times.
The cost of the blaze could be immense given the likely high volume of inventory inside the warehouse.
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Ozone press spokespersons, quoted in RB.RU said: “There was a fire in a separate block of the fulfilment centre in New Riga.
“All employees were evacuated from the warehouse.
“No one was injured beforehand, the information is being clarified.
“Firefighters work on the spot, ambulance services are on duty.”